Inflammation in Cardiovascular Disease

Inflammation in Cardiovascular Disease

In 1998, I wrote an editorial that attempted to make two points.2 The first point was biological: there existed at that time an active debate over whether inflammation was a cause or a result of cardiovascular disease (CVD), and I suggested that this debate was in fact based on a false distinction, and that both positions where likely to be correct. While atherothrombotic disease is inflammator...

Inflammation in Cardiovascular Disease

Inflammation and cardiovascular disease

There now exists overwhelming evidence supporting the inflammatory hypothesis of atherosclerotic vascular disease. Cellular interactions between leukocytes, platelets and endothelial cells are critical in the initiation and progression of atherosclerotic disease. Acute coronary syndromes, namely unstable angina and acute myocardial infarction, and thromboembolic stroke represent acute unstable ...

Cell Therapy in Cardiovascular Disease

  Recently, cell therapy has sparked a revolution in ischemic heart disease that will in the future help clinicians to cure patients. Earlier investigations in animal models and clinical trials have suggested that positive paracrine effects such as neoangiogenesis and anti-apoptotic can improve myocardial function. In this regard the Royan cell therapy center designed a few trials in collaborat...

Depression, Inflammation, and Cardiovascular Disease

1. The Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346:549 –56. 2. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002;346:557– 63. 3. Boddicker KA, Zhang Y, Zimmerman MB, Davies LR, Kerber RE. Hy...